| 摘要 |
<p>A method for making a transdermal drug delivery device for heat sensitive and volatile drugs is disclosed. The device contains a drug-containing adhesive composite layer having an impermeable backing material laminated to the distal surface thereof and a proximal peelable impermeable backing material adapted for removal for administering a drug to the skin or mucosa laminated to the proximal surface thereof. The figure provides a partly schematic, sectional view of the transdermal drug delivery device (10) including the substantially drug-impermeable distal backing (14), a drug laden adhesive composite (18) and a substantially drug impermeable proximal release liner (22). The adhesive composite (18) is comprised of a distal adhesive layer (19), a proximal adhesive layer (20) and a gelled drug layer (21) disposed therebetween. The device is produced by extruding the drug in gel form onto at least one exposed surface of a first or second adhesive laminate such that the adhesive layers and gelled drug are combined to form the drug-containing adhesive composite layer having the distal and proximal surfaces covered by the respective backing materials. This process is particularly adaptable to the formulation of nicotine-containing patches.</p> |
