PROCESS FOR THE PREPARATION OF AN ANTIBIOTIC

摘要

The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a beta -lactam core is acylated, the antibiotic is recovered from the reaction mixture, the remaining mother liquor is subjected to a hydrolysis reaction in which the antibiotic present in the mother liquor is decomposed into its initial compounds, in particular the beta -lactam core, and the acylation agent is hydrolized. The beta -lactam core can then be recovered virtually quantitatively or recycled to the acylation reaction. This is because it has been found that the solubility of the beta -lactam core is unexpectedly high at relatively high concentrations of acylation agent and antibiotic.