| 发明名称 |
Inhibitors of interleukin-1beta converting enzyme |
| 摘要 |
The present invention relates to novel classes of compounds which are inhibitors of interleukin-1 beta converting enzyme. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against interleukin-1 and apoptosis-mediated diseases, including inflammatory diseases, autoimmune diseases, proliferative, infectious, and degenerative diseases. This invention also relates to methods for inhibiting ICE activity and methods for treating interleukin-1 mediated diseases using the compounds and compositions of this invention. |
| 申请公布号 |
ZA9610797(B) |
申请公布日期 |
1997.06.26 |
| 申请号 |
ZA19960010797 |
申请日期 |
1996.12.20 |
| 申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
GUY W. BEMIS;JOHN P. DUFFY;WOLF HERMAN FRIDMAN;JULIAN M. C. GOLEC;DAVID J. LIVINGSTON;MICHAEL D. MULLICAN;MARK A. MURCKO;ROBERT E. ZELLE |
| 分类号 |
A61K38/00;A61K38/55;A61P1/00;A61P1/04;A61P1/16;A61P1/18;A61P3/10;A61P5/14;A61P7/00;A61P7/06;A61P9/10;A61P11/00;A61P11/06;A61P13/12;A61P17/00;A61P17/06;A61P17/14;A61P19/02;A61P19/08;A61P19/10;A61P21/00;A61P21/04;A61P25/00;A61P25/16;A61P25/28;A61P29/00;A61P31/00;A61P35/00;A61P35/02;A61P37/02;A61P43/00;C07K5/00;C07K5/02;C07K5/08;C07K5/083 |
主分类号 |
A61K38/00 |
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