发明名称 |
BENZAZEPINE DERIVATIVES WITH VASOPRESSIN AGONISTIC ACTIVITY |
摘要 |
Novel benzazepine derivative of formula (1) wherein R1 is H or halogen, A is low er alkylene, R2 and R3 are the same or different and each H, lower alkoxy, lower alkyl having optionally a lower alkoxy substituent, etc., or R2 and R3 may combine together with the nitrogen to which they bond to form a 5- to 7-membered saturated heterpcyclic group which may optionally be substituted by a lower alkyl, etc., R4 is H, lower alkyl, OH, etc., R5 is -NHR6 (R6 is lower alkyl) or pyrrolidinyl, or a salt thereof, which show excellent anti-vasopressin activity, oxytocin antagonistic activity and vasopressin agonistic activity, and are useful as a vasopressin antagonist, a vasopressin agonist and an oxytocin antagonist.
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申请公布号 |
CA2239547(A1) |
申请公布日期 |
1997.06.26 |
申请号 |
CA19962239547 |
申请日期 |
1996.12.13 |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
TANADA, YOSHIHISA;KURIMURA, MUNEAKI;MORITA, SEIJI;UCHIDA, MINORU;MORI, TOYOKI;YABUUCHI, YOICHI;TOMINAGA, MICHIAKI;KONDO, KAZUMI;SHINOHARA, TOMOICHI;KAN, KEIZO;OGAWA, HIDENORI |
分类号 |
A61K31/55;C07D223/16;C07D401/06;C07D401/12;C07D401/14;C07D403/06;C07D403/12;C07D413/06;C07D417/12;(IPC1-7):C07D403/12 |
主分类号 |
A61K31/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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