MURINE MONOCLONAL ANTI-IDIOTYPE ANTIBODY 11D10 AN METHODS OF USE THEREOF
摘要
The present invention provides a monoclonal anti-idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D10 was selected by specific procedures. 11D10 induces an immunological response to HMFG in mice, rabbits, monkeys and patients with advanced HMFG-associated tumors. This invention provides compositions derived from polynucleotide sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody 11D10, as well as polypeptides encoded thereby. The invention also provides compositions which can be used in the detection or treatment of HMFG-associated tumors.
申请公布号
WO9722699(A2)
申请公布日期
1997.06.26
申请号
WO1996US20757
申请日期
1996.12.19
申请人
UNIVERSITY OF KENTUCKY;CHATTERJEE, MALAYA;FOON, KENNETH, A.;CHATTERJEE, SUNIL, K.
发明人
CHATTERJEE, MALAYA;FOON, KENNETH, A.;CHATTERJEE, SUNIL, K.