| 摘要 |
Cascade polymer complexes contain: (a) complexing ligands of general formula (I), in which A stands for a nitrogenated cascade core of basic multiplicity a; X and Y independently represent a direct bond or a cascade reproduction unit of reproduction multiplicity x or y; Z and W independently represent a cascade reproduction unit of reproduction multiplicity z or w; K stands for a complexing agent residue; a equals 2 to 12; x, y, z and w independently represent the integers 1 to 4, provided that at least two reproduction units be different, that 16</=1.x.y.z.w</=64 applies to the product of the multiplicities and that at least one of the cascade reproduction units X, Y, Z, W stand for a 1,4,7,10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane reproduction unit; (b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83; optionally (c) cations of inorganic and/or organic bases, amino acids or amino acid amides; and (d) optionally acylated terminal amino groups. These compounds are useful in diagnosis and therapy.
|
| 申请人 |
SCHERING AG, 13353 BERLIN, DE |
发明人 |
SCHMITT-WILLICH, HERIBERT, DR., 12161 BERLIN, DE;PLATZEK, JOHANNES, DR., 12621 BERLIN, DE;RADUECHEL, BERND, DR., 13465 BERLIN, DE;WEINMANN, HANNS-JOACHIM, DR., 14129 BERLIN, DE;EBERT, WOLFGANG, DR., 12203 BERLIN, DE;MISSELWITZ, BERND, DR., 13439 BERLIN, DE;MUEHLER, ANDREAS, DR., 15366 NEUENHAGEN, DE;FRENZEL, THOMAS, DR., 12247 BERLIN, DE |
