发明名称 |
SUSTAINED RELEASE PREPARATION CONTAINING METAL SALT OF A PEPTIDE |
摘要 |
A sustained-release preparation containing a water-insoluble or slightly water-soluble polyvalent metal salt of a water-soluble peptide type of physiologically active substance except for an endothelin antagonist and a biodegradable polymer. The present invention is a sustained-release preparation that is highly efficient in incorporating a water-soluble peptide type of physiologically active substance except for an endothelin antagonist and suppresses initial burst of the water-soluble peptide type of physiologically active substance except for an endothelin antagonist. The sustained-release preparation of the present invention is capable of releasing the water-soluble peptide type of physiologically active substance except for an endothelin antagonist while retaining its bioactivity after administration in vivo. Furthermore, the water-soluble peptide type of physiologically active substance except for an endothelin antagonist in the sustained-release preparation is kept stable for a long period of time, with little loss of bioactivity. |
申请公布号 |
EP0779806(A1) |
申请公布日期 |
1997.06.25 |
申请号 |
EP19950930707 |
申请日期 |
1995.09.06 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
IGARI, YASUTAKA;YAMAGATA, YUTAKA;IINUMA, SATOSHI;OKADA, HIROAKI |
分类号 |
A61K9/16;A61K9/50;A61K38/18;A61K38/19;A61K38/21;A61K38/27;A61K38/28;(IPC1-7):A61K9/16 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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