Halogenated DNA ligand radiosensitizers for cancer therapy

摘要

A radiosensitizer for use in radiotherapy comprises a halogenated DNA ligand. The susceptibility of DNA to radiation damage is enhanced by causing or allowing the halogenated DNA ligand to bind to the DNA before subjecting the DNA or the locus thereof to ionizing or ultraviolet radiation. Radiation damage in DNA is also induced by causing or allowing a halogenated DNA ligand to bind to DNA and irradiating the DNA and said bound ligand or the locus thereof with ionizing or ultraviolet radiation.