发明名称 Prodrugs of thrombin inhibitors
摘要 In the present invention, there are described peptide derivatives of the general formula Re1O(O)C-C-CHi2-(R)Cgl-Aze-Pab-Re2, wherein the substituents have specific meanings, pharmaceutically acceptable salts thereof, processes of their preparation, pharmaceutical compositions in which the derivatives are comprised as well as their use for preparing a medicament intended for treating conditions requiring thrombin inhibition and for use in the treatment thrombosis and as an anticoagulant.
申请公布号 ZA9610353(B) 申请公布日期 1997.06.23
申请号 ZA19960010353 申请日期 1996.12.09
申请人 ASTRA AKTIEBOLAG 发明人 THOMAS ANTONSSON;DAVID GUSTAFSSON;KURT-JUERGEN HOFFMANN;JAN-ERIK NYLSTROEM;HENDRIK SOERENSE;MIKAEL SELLEN
分类号 C12N9/99;A61K;A61K38/55;A61P7/02;A61P9/10;A61P43/00;C07K;C07K1/02;C07K5/00;C07K5/06;C07K5/065 主分类号 C12N9/99
代理机构 代理人
主权项
地址