| 摘要 |
FIELD: medicinal biotechnology, virology. SUBSTANCE: invention proposes the strain "Orloff-B", "ГКВ" N 2326 and describes the following strain properties: cultural-morphological characters (buoyant density is 1.18-1.20 g/$$$, titer = 4-6 lg $$$/0.5 ml and 7-8 lg $$$/0.5 ml on cells BHK-21); physiological-biochemical characters (optimum pH = 7.4, inactivation at 56 C for 30 min, sensitivity to ether and acetone); antigenic properties (hemagglutinating activity in vitro - 2-8 "ГАЕ"); immunogenic properties (100% formation of specific antibody in rabbits and guinea pigs, at reverse titer in "РТГА" - from 640-2560 to 1280-10240, respectively; serum conversion is 80-100%); virulent properties (strain does not show virulent or contagious properties); toxicity (no toxicity at dose 1000 $$$/0.5 ml in guinea pigs and mice). EFFECT: enhanced immunogenicity of vaccine against measles, improved properties of strain-producer. 3 tbl |
