| 摘要 |
A process to make .alpha., .alpha.-difluoro-.beta.-hydroxy thiol esters of formula (IIIA), comprising reacting a difluoroethanethioate of formula (IVA), with a second reactant selected from the group consisting of aldehydes, ketones, acid halides and esters; in a solvent and in the presence of a strong base; with the proviso that the process is conducted in the absence of a catalyst and in the absence of a silyl containing compound is described and claimed. The .alpha., .alpha.-difluoro-.beta.-hydroxy thiol esters can be useful in the syntheses of organic compounds including gemcitabine hydrochloride.
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