| 摘要 |
The invention concerns a method of producing morphologically uniform microcapsules containing peptides, proteins or other water-soluble biologically active substances as active substance, and microcapsules produced by this method with a charging degree of between 3 and 30 wt.% and a diameter of </= 8 mu m. According to the invention, biodegradable polymers are dissolved in a halogen-free solvent or solution mixture and the buffered active substance solution, which has a pH of between 6.0 and 8.0, is dispersed in this solution. An aqueous solution containing a surfactant is then added to this W/O emulsion (W/O/W emulsion) and the solvent removed. The microcapsules produced by this method display no tendency to agglomerate. The encapsulation efficiency of the method is between 90 and 95 %.
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| 申请人 |
SCHERING AG, 13353 BERLIN, DE |
发明人 |
ROESLING, GEORG, DR., 13465 BERLIN, DE;ALBAYRAK, CELAL, DR., 10999 BERLIN, DE;TACK, JOHANNES, DR., 13595 BERLIN, DE;SCHMITZ, REINHARD, 10719 BERLIN, DE |
