发明名称 |
AGENTS FOR PROMOTING BONE FORMATION |
摘要 |
The object is to provide a promoting agent for bone formation, a therapeutic method for bone formation and a process for preparing a promoting agent for bone formation. A promoting agent for bone formation which comprises at least one of kistrin, echstatin, a peptide or polypeptide containing the amino acid sequence ArgGlyAsp in the molecule such as a peptide represented by Gly-Arg-Gly-Asp-Ser or a compound represented by general formula (IX) and so on, as well as a biologically acceptable salt thereof, wherein R16 represents -N(R20)2 (R20 represents a hydrogen atom or a C1-C4 alkyl group), R17 represents a hydrogen atom or a C1-C4 alkyl group, R18 represents a hydrogen atom, a C1-C4 alkyl group and so on, R19 represents OH, NH2 and so on, Y represents -NH-, -O- or a direct bond, a represents 1-3, b represents 1 or 2, c represents 0 or 1 and d represents 0 or 1.
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申请公布号 |
WO9721726(A1) |
申请公布日期 |
1997.06.19 |
申请号 |
WO1996EP05380 |
申请日期 |
1996.12.06 |
申请人 |
ROUSSEL UCLAF;KITAMURA, KAZUYUKI;KOMIYAMA, OSAMU;INAZU, MIZUHO;BARON, ROLAND;GADEK, THOMAS;KNOLLE, JOCHEN;STILZ, HAN-ULRICH;WEHNER, VOLKMAR;MCDOWELL, ROBERT, S. |
发明人 |
KITAMURA, KAZUYUKI;KOMIYAMA, OSAMU;INAZU, MIZUHO;BARON, ROLAND;GADEK, THOMAS;KNOLLE, JOCHEN;STILZ, HAN-ULRICH;WEHNER, VOLKMAR;MCDOWELL, ROBERT, S. |
分类号 |
C07D233/76;A61K31/00;A61K31/195;A61K31/415;A61K31/4166;A61K38/00;A61K38/04;A61K38/05;A61K38/07;A61K38/12;A61K38/17;A61K38/39;A61P19/00;A61P19/08;A61P43/00;C07C271/22;C07C279/08;C07C279/20;C07K5/02;C07K5/09;C07K5/097;C07K5/11;C07K5/117;C07K7/06;C07K14/46;C07K14/745;C07K14/78;(IPC1-7):C07K7/06;C07K14/705 |
主分类号 |
C07D233/76 |
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