摘要 |
<p>The present invention is a method of treating non-insulin-dependent diabetes mellitus comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of general formula (I) for a period of time of more than 6 days, wherein Y is O; R is OH, NHCONR4R5, or N=C(NR4R5)2; R?4 and R5¿ are each independently selected from the group consisting of hydrogen; C¿1-10? alkyl, straight or branched chain; aryl C1-4 alkyl; and mono- or disubstituted aryl C1-4 alkyl where the substituents are fluoro, chloro, bromo, iodo or C1-10 alkyl, straight or branched chain; R?1 and R2¿ are each independently selected from the group consisting of hydrogen, amino, and mono- or di-substituted chain C¿3-8?, cycloalkyl; provided that R?1 and R2¿ may not both be amino or substituted amino; and R3 is hydrogen, trifluoromethyl, fluoro, chloro, bromo, or iodo; or a pharmaceutically acceptable salt thereof.</p> |