发明名称 |
USE OF BICYCLIC MONO- OR DIKETONE DERIVATIVES, RESULTING COMPOUNDS, AND USE THEREOF AS A DRUG FOR TREATING INFLAMMATION, MIGRAINE AND SHOCK |
摘要 |
The therapeutical use of bicyclic derivatives and pharmaceutically acceptable salts thereof having general formula (I), wherein each of X1, X2, X3 and X4 is independently a carbon atom or a nitrogen atom, with n being 0 or 1; A is selected from an oxygen atom and a carbonyl grouping; each of R1 and R2 is independently either: a hydrogen atom; or an optionally substituted aromatic ring or an optionally substituted heteroaromatic ring having one or more heteroatoms, a saturated ring optionally having one or more heteroatoms, optionally substituted by an alkyl chain; or a chain having 1-4 atoms, consisting of optionally substituted nitrogen, a carbonyl grouping optionally terminated with an optionally substituted aromatic ring or an optionally substituted heteroaromatic ring optionally having one or more heteroatoms; R3 is a hydrogen atom, a halogen atom, a C1-5 alkyl radical, a nitrogen radical substituted by two groupings that are each independently a hydrogen atom or a C1-5 alkyl grouping optionally incorporating a carbonyl grouping, or an aromatic ring; and R4 is a hydrogen atom, a halogen atom, a C1-5 alkyl radical, or an optionally substituted oxygen-containing derivative, with the exception of 6-phenylamino-5,8-quinolinedione and 2-N-acetylamino-1,4-naphthoquinone. |
申请公布号 |
WO9721432(A1) |
申请公布日期 |
1997.06.19 |
申请号 |
WO1996FR01972 |
申请日期 |
1996.12.10 |
申请人 |
LABORATOIRE INNOTHERA, S.A.;BOUTHERIN-FALSON, ODILE;DESQUAND-BILLIALD, STEPHANIE;FAVROU, ANITA;FINET, MICHEL;TEMBO, OLIVIER;TORREGROSA, JEAN-LUC;YANNIC-ARNOULT, SYLVIE |
发明人 |
BOUTHERIN-FALSON, ODILE;DESQUAND-BILLIALD, STEPHANIE;FAVROU, ANITA;FINET, MICHEL;TEMBO, OLIVIER;TORREGROSA, JEAN-LUC;YANNIC-ARNOULT, SYLVIE |
分类号 |
C07D295/08;A61K31/00;A61K31/135;A61K31/136;A61K31/165;A61K31/167;A61K31/17;A61K31/35;A61K31/352;A61K31/357;A61K31/36;A61K31/40;A61K31/403;A61K31/404;A61K31/47;A61K31/472;A61K31/495;A61K31/4965;A61K31/535;A61K31/5375;A61P9/00;A61P9/14;A61P17/00;A61P19/00;A61P19/02;A61P25/06;A61P29/00;C07C225/30;C07C233/32;C07C243/38;C07C275/30;C07D209/08;C07D213/74;C07D213/86;C07D215/24;C07D217/02;C07D237/28;C07D237/30;C07D239/74;C07D241/42;C07D295/116;C07D311/22;C07D311/36;C07D319/20 |
主分类号 |
C07D295/08 |
代理机构 |
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代理人 |
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