| 发明名称 |
NOVEL TYROSINE KINASE RECEPTORS AND LIGANDS |
| 摘要 |
The present invention provides for a gene, designated as musk, that encodes a novel tyrosine kinase receptor expressed in high levels in denervated muscle. The invention also provides for an isolated polypeptide which activates MuSK receptor. The invention further provides for a polypeptide which is functionally equivalent to the MuSK activating polypeptide. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the musk gene product. The present invention also provides for diagnostic and therapeutic methods based on molecules that activate MuSK.
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| 申请公布号 |
CA2240516(A1) |
申请公布日期 |
1997.06.19 |
| 申请号 |
CA19962240516 |
申请日期 |
1996.12.13 |
| 申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
BOWEN, DAVID C.;GLASS, DAVID J.;YANCOPOULOS, GEORGE D.;VALENZUELA, DAVID M. |
| 分类号 |
C12N15/09;A61K31/00;A61K38/00;A61K48/00;A61P21/00;C07K14/705;C07K14/78;C07K14/81;C07K16/38;C07K16/40;C12N1/19;C12N1/21;C12N5/10;C12N9/12;C12N15/12;C12P21/08;C12R1/19;C12R1/84;G01N33/53;G01N33/566;(IPC1-7):C12N15/12;C07K17/08;A61K38/17;C07K16/18;C07K14/47;C12Q1/68;A61K31/70 |
主分类号 |
C12N15/09 |
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