| 摘要 |
<p>Methods and compositions for using the OX-2 protein to modulate a T cell mediated immune response are described. Novel structure forms of the OX-2 T cell costimulatory molecules also are described. These structural forms comprise a novel structure domain or have a structural domain deleted. The structural forms correspond to naturally-occurring alternatively-spliced forms of OX-2 T cell costimulatory molecules or variants thereof which can be produced by standard recombinant DNA techniques. The novel structure forms of the OX-2 T cell costimulatory molecules can be used to identify agents which stimulate the expression of alternative forms of costimulatory molecules and to identify components of the signal transduction pathway which results in costimulation of T cells.</p> |
