Process for creating a skin substitute and the resulting skin substitute

摘要

The invention concerns a process for obtaining a skin substitute and the skin substitute itself. According to this process, a dermis substitute is prepared by mixing contractile cells, a nutritive medium, and collagen, in order to form a contracting gel; this dermis substitute is used as a substrate for an epidermis substitute obtained by culturing, using keratinocytes from an animal or human skin sample. According to the invention, the substrate is implanted with at least one section of a hair follicle retaining at least partially its cellular sheath, this section being implanted perpendicularly to the free surface of the substrate.