| 摘要 |
<p>An inducible or regulatable retroviral vector for the controlled delivery of a gene product, and in particular, a tetracycline regulated retroviral vector for the controlled delivery of a gene product is disclosed. This retroviral vector contains the following DNA sequences operatively linked from 5' to 3': (a) DNA comprising a first promoter; (b) DNA comprising a second promoter different from the first promoter in (a) and different from the third promoter in (e); (c) DNA encoding a tetracycline regulator unit (tTA) under the transcriptional control of said second promoter; (d) DNA encoding a tetracycline response unit (tetO) in an antisense orientation relative to said DNA encoding said regulator unit of (c); and (e) DNA comprising a third promoter different from the first promoter in (a) and different from the second promoter in (b) wherein said DNA encoding said response unit of (d) is under the transcriptional control of said third promoter.</p> |
