REVERSED PHASE CHROMATOGRAPHIC PROCESS

摘要

A factory scale process for the reversed phase chromatographic decolorisation, separation and purification of water-soluble nonionic contrast media compounds from solutions containing nonionic compound impurities includes the steps of passing a solution through a decoloriser chromatographic column (2) and eluting the decoloriser column (2) with solvent. The packing in the decoloriser column (2) is regenerated by passing a regenerating solvent (20) through the packing, purifying the solvent (21) in a solvent recovery plant (25) and recycling the solvent. Waste solvent (33) produced on regenerating a purification column used in a recovery process may also be recovered in the solvent recovery plant (25).