STRATEGY FOR SUPPRESSING THE EXPRESSION OF AN ENDOGENEOUS GENE BY USING COMPOUNDS THAT ARE ABLE TO BIND TO THE NON-CODING REGIONS OF THE GENE TO BE SUPPRESSED
摘要
The invention provides strategy for suppressing expression of an endogenous gene, wherein said strategy comprises providing suppression effectors able to bind to the non-coding regions of a gene to be suppressed, to prevent the functional expression thereof. The suppression effectors may be antisense nucleic acids, and the non-coding regions can include the transcribed but non-translated regions of a gene. The strategy can also introduce a replacement gene.
申请公布号
WO9711169(A3)
申请公布日期
1997.06.12
申请号
WO1996GB02357
申请日期
1996.09.23
申请人
PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF TH;FARRAR, GWENYTH, JANE;HUMPHRIES, PETER;KENNA, PAUL, FRANCIS
发明人
FARRAR, GWENYTH, JANE;HUMPHRIES, PETER;KENNA, PAUL, FRANCIS