发明名称 |
Methods for determining compounds capable of inhibiting the activities of the ha-ras oncogene |
摘要 |
This invention provides a method for determining whether a compound is capable of suppressing ras functions comprising: (a) contacting an effective amount of the compound with Ha-ras transformed cloned rat embryo fibroblast cells under conditions permitting the compound to suppress ras functions in the cells; and (b) determining the expression or inhibition of certain indicator gene or genes, thereby determining whether the compound is capable of suppressing ras function. This invention further provides the determined compound and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier. This invention also provides methods for generating transcriptional switched Ha-ras transformed cloned rat embryo fibroblast cells. This invention also provides the generated cells and different uses of the cells. |
申请公布号 |
AU1163097(A) |
申请公布日期 |
1997.06.11 |
申请号 |
AU19970011630 |
申请日期 |
1996.11.22 |
申请人 |
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE |
发明人 |
PAUL B FISHER;ZAO-ZHONG SU |
分类号 |
C12N15/09;A61K31/00;A61K38/00;A61K45/00;A61P35/00;C07K2/00;C07K14/47;C07K14/82;C12N5/10;C12Q1/26;C12Q1/34 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|