| 摘要 |
PCT No. PCT/JP93/01603 Sec. 371 Date Jun. 15, 1995 Sec. 102(e) Date Jun. 15, 1995 PCT Filed Nov. 5, 1993 PCT Pub. No. WO94/10998 PCT Pub. Date May 26, 1994In producing a composition for solid medicine, comprising, as an active ingredient, a potassium channel activator and a pharmaceutically acceptable water-insoluble cellulose polymer, a method for producing a composition for solid medicine, which is characterized by dissolving a potassium channel activator in a solvent to give a medical solution, adding said medical solution to a water-insoluble cellulose polymer inert to said solvent in an amount necessary and sufficient to achieve a predetermined elution rate, homogeneously mixing them and drying the mixture to remove the solvent, and a composition for solid medicine, which is obtainable by said production method. According to the method of the present invention, elution rate of the active ingredient of a preparation comprising a potassium channel activator, which is a sustained release preparation, can be controlled with ease and with good reproducibility.
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