Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid

摘要

A method of making (+/-)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with <IMAGE> to form primarily <IMAGE>to form <IMAGE> decarboxylating the <IMAGE> to form <IMAGE> hydrolyzing the <IMAGE> with an alkali or alkaline earth metal hydroxide to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (+/-)-3-(aminomethyl)-5-methylhexanoic acid, wherein R1 and R2 are the same or different and are hydrogen, C1-C6 alkyl, aryl, benzyl, or C3-C6 cycloalkyl. The present invention also provides a method of making (+/-)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with <IMAGE> to form primarily <IMAGE> reacting the <IMAGE> with a cyanide source to form <IMAGE> decarboxylating the <IMAGE> to form an alkali or alkaline earth metal carboxylate salt; and hydrogenating the alkali or alkaline earth metal carboxylate salt to form (+/-)-3-(aminomethyl)-5-methylhexanoic acid.