发明名称 |
Process for the preparation of etoposide phosphate and intermediate thereof |
摘要 |
An etoposide phosphate represented by the formula <IMAGE> (1) is prepared by blocking the hydroxyl groups of the saccharide moiety of etoposide with halogenoacetyl groups, thereafter phosphorylating the 4'-position, and removing the halogenoacetyl groups from the obtained phosphate in the presence of an amine. This process can give the objective etoposide phosphate in a higher yield than that of the prior art to enable the industrial mass-production thereof.
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申请公布号 |
US5637680(A) |
申请公布日期 |
1997.06.10 |
申请号 |
US19950479811 |
申请日期 |
1995.06.07 |
申请人 |
NIPPON KAYAKU KABUSHIKI KAISHA |
发明人 |
MIYAZAWA, YOSHINOBU;SATO, HITOSHI;YOSHIKAWA, HIROSHI;OHKAWA, KOUICHI;TOMIYOSHI, NORIKO |
分类号 |
C07H17/04;(IPC1-7):A61K31/70 |
主分类号 |
C07H17/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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