Suksdorfin analogs, compositions thereof, and methods for making and using thereof

摘要

Compounds, including compositions and methods of making and using these compounds for treating retroviral infections, are provided according to formula (G-1): <IMAGE> (G-1) wherein M is O or NH; Z is O, NH or S; R240, and R250 are each H, C1-10 alkyl, C1-10 aryl, alkyl, amide, or CH2COOR260, where R260 is C1-10 alkyl or acyl; R200, R210, R220 and R230 are each H, halogen, hydroxyl, NH2, NH-alkyl, N-(alkyl)2, O-alkyl, O-acyl, COCF3, OCF3 or CH2COO NH-alkyl; or R200 and R210 form C5-C10 cyclo or heterocyclo optionally substituted with one or more of halogen, hydroxyl, NH2, NH-alkyl, N-(alkyl)2, O-acyl, O-alkyl, CO, CF3, OCF3 or CH2 COONH-alkyl; wherein C3 and C4 can be bound by a single or double bond; configurations at 3' or 4' can be (R) or (S); and R240 and R250 are either cis- beta or cis alpha , or trans-3'- alpha or trans-3'- beta oriented. Stereoselectivity can be enhanced by preparing these compounds by catalytic asymmetric dihyroxylation.