Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

摘要

The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, and R'9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.