THIAZOLIDEN-2,4-DIONE DERIVATIVE, PROCESS FOR PREPARATION THEREOF, THIAZOLIDIN-2,4-DIONE DERIVATIVE AS INTERMEDIATE PRODUCT WHEN PREPARING AROMATIC AMINOALCOHOL DERIVATIVES

摘要

Compounds of formula (I) : (in which: R<0> is hydrogen, methyl or hydroxymethyl; R<1> is substituted alkyl; R<2> and R<3> are each hydrogen, halogen, hydroxy, alkoxy, carboxy, alkoxycarbonyl, alkyl, nitro, haloalkyl, or substituted alkyl; X is oxygen atom or a sulphur; and Ar optionally substituted phenyl or naphthyl); and pharmaceutically acceptable salts thereof have a variety of valuable pharmaceutical activities, including anti-diabetic and anti-obesity activities; in addition, they are capable of treating or preventing hyperlipemia and hyperglycemia and, by inhibiting the action of aldose reductase, they can also be effective in the treatment and prevention of complications of diabetes.