发明名称 |
Förfarande för framställning av mellanprodukter, som är användbara i syntes av cefalosporiner |
摘要 |
<p>A process is described for preparing 3-exomethylene cephalosporanic acid derivatives for use in the synthesis of cephalosporin antibiotics such as ceftibuten. The process comprises electrochemical reduction of a compound of the formula (IV) <IMAGE> (IV) wherein: R3 is CH3C(O)-; <IMAGE> is an optional sulfoxide group; n is 2 or 3; R1 is H and R is H or NHR2, where R2 is H or a protecting group selected from C6H5CH2OC(O)-, C6H5C(O)- or C1-C6 alkoxy-C(O)-; or wherein R and R1 together with the carbon atom to which they are attached comprise -C(O)-, and produces the desired 3-exomethylene compounds with low levels of the corresponding 3-methyl tautomers.</p> |
申请公布号 |
FI972440(A) |
申请公布日期 |
1997.06.09 |
申请号 |
FI19970002440 |
申请日期 |
1997.06.09 |
申请人 |
SCHERING CORPORATION;ANTIBIOTICOS |
发明人 |
WALKER, DEREK;LEE, JUNNING;MARTIN, CHARLES R.;ZHANG, HAIYAN;SOGLI, LORIS;BERNASCONI, ERMANNO;MENON, VINOD P. |
分类号 |
C07D501/00;C07D501/04;C07D501/12;C07D501/14;C07D501/18;C07D501/22;C07D501/24;C07D501/59;C25B3/04;(IPC1-7):C07D |
主分类号 |
C07D501/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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