RECOMBIANT ADENOVIRUS AND ADENO-ASSOCIATED VIRUS, CELL LINES, AND METHODS OF PRODUCTION AND USE THEREOF
摘要
A novel adenovirus E1/E4 expressing packaging cell line is provided, which permits the generation of recombinant adenoviruses deleted in both gene regions. The E1/E4 deleted recombinant adenovirus is capable of expressing a selected transgene product in cells in vivo or in vitro. This recombinant virus is useful in the treatment of genetic disorders.
申请公布号
WO9639530(A3)
申请公布日期
1997.06.05
申请号
WO1996US10245
申请日期
1996.06.04
申请人
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;WILSON, JAMES, M.;FISHER, KRISHNA, J.;GAO, GUANG-PING