USE OF NADPH OXIDASE INHIBITORS FOR THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION OF ATHEROSCLEROSIS

摘要

A method for the prevention and treatment of atherosclerosis and its related diseases in mammals, in which an NADPH oxidase inhibitor is administered, is provided. The NADPH oxidase inhibitor prevents the production of reactive oxygen species upon exposure of endothetial cells to atherogenic LDL levels, thus resulting in decreased endocytosis and vascular hyperpermeability. Preferred NADPH oxidase inhibitors are of formula (I). Additionally, there i s provided a diagnostic method for predicting risk of a human patient to atherosclerotic-related diseases.