SUBSTITUTED PIPERAZINE DERIVATIVES

摘要

A compound of formula (I), or a salt or prodrug thereof, wherein L is selected from (A) wherein G represents oxygen or sulphur; M represents halogen or C1-6 alkyl; R<1> represents aryl or heteroaryl, either of which groups may be optionally substituted; (B) wherein Ar is a six-membered aromatic ring optionally containing one or two nitrogen atoms, which ring is optionally substituted; and (C) wherein R<8> is phenyl, optionally substituted. R<9> and R<10> are independently selected from hydrogen, C1-6 alkyl, C2-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and halogen, R<9> and R<10>, together with the carbon atom to which they are attached, form a C3-7 cycloalkyl group; processes for its preparation and its use in the treatment of conditions for which the administration of an agonist selective for the 5-HT1Dalpha receptor subtype is indicated, such as migraine.