SÄUREANHYDRIDE, IHRE HERSTELLUNG UND IHRE VERWENDUNG

摘要

PCT No. PCT/FR93/00111 Sec. 371 Date Aug. 3, 1994 Sec. 102(e) Date Aug. 3, 1994 PCT Filed Feb. 4, 1993 PCT Pub. No. WO93/16058 PCT Pub. Date Aug. 19, 1993This invention relates to novel anhydrides of general formula (I), (I) wherein Ar is an aryl radical, and either R1 is C6H5-CO or (CH3)3C-O-CO, R2 is a hydrogen atom and R3 is a hydroxy function protective grouping, or R1 is (CH3)3C-O-CO and R2 together form a saturated 5 or 6-membered heterocyclic ring; preparation thereof; and uses thereof for preparing taxane derivatives having general formula (III), (III) wherein R=H, acetyl; R1 is C6-H5-CO or (CH3)3C-O-CO), and having antitumoral properties.