发明名称 |
AN IMPROVED METHOD FOR PREPARATION OF SUBSTITUTED TETRAHYDROISOQUINOLINES |
摘要 |
An improved method for the preparation and isolation of optically pure (3S) or (3R)-1, 2, 3, 4-tetrahydroisoquinoline-3-carboxylic acid comprises reacting formaldehyde with either D- or L-phenylalanine and hydrobromic acid to prepare the pure hydrobromide salts. The mixture is then cooled to precipitate the optically pure isomer which is filtered and then neutralized with a base to form the free acid and dried. |
申请公布号 |
WO9717050(A3) |
申请公布日期 |
1997.06.05 |
申请号 |
WO1996US17926 |
申请日期 |
1996.11.08 |
申请人 |
MONSANTO COMPANY |
发明人 |
GRIFFIN, BRIAN;JOHNSON, MARK, R.;KELLER, RONALD, L. |
分类号 |
C07D217/26 |
主分类号 |
C07D217/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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