Process for the preparation of (24R)-24,25-dihydroxysteroid compounds

摘要

A process for producing a (24R)-24,25-dihydroxysteroid compound which comprises carrying out a catalytic asymmetric dihydroxylation reaction on a steroid compound having a carbon-carbon double bond in the side chain in the presence of an osmium complex having a hydroquinidine derivative using a heterogeneous solvent system prepared by adding at least one organic solvent selected from tetrahydrofuran, acetonitrile, acetone, 1,4-dioxane, N,N-dimethylformamide and N,N-dimethylacetamide to a tert-butanol/water two-component solvent system.