发明名称 |
Long-lasting release nifedipine preparation |
摘要 |
This invention provides a long-lasting release solid nifedipine preparation which exhibits clinically sufficient effect when administered once per day. ÄConstructionÜ A press coated tablet whose core and shell each contains nifedipine, the dissolution rate of nifedipine from said tablet being (a) in the dissolution test using a sinker according to method 2 of the dissolution test method as prescribed by the Pharmacopoeia of Japan, after 2 hours 10-40% after 4 hours 30-65% after 6 hours at least 55%, and (b) in the dissolution test according to the disintegration test method as prescribed by the Pharmacopoeia of Japan, after 3 hours 20-45% after 4 hours 30-65%. c
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申请公布号 |
EP0776660(A2) |
申请公布日期 |
1997.06.04 |
申请号 |
EP19960118311 |
申请日期 |
1996.11.15 |
申请人 |
BAYER AG |
发明人 |
NISHIOKA, TAKAAKI;KURATANI, KENJI;KANASAKI, HARUO;LUCHTENBERG, HELMUT, DR.;TENTER, ULRICH, DR.;OHM, ANDREAS, DR. |
分类号 |
A61K9/28;A61K9/24;A61K31/4422;A61K31/455;A61K47/32;A61K47/38;A61P9/08;A61P9/10;(IPC1-7):A61K9/24;A61K31/44 |
主分类号 |
A61K9/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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