发明名称 |
Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging |
摘要 |
Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.
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申请公布号 |
US5635157(A) |
申请公布日期 |
1997.06.03 |
申请号 |
US19930132201 |
申请日期 |
1993.10.06 |
申请人 |
MEASE, RONNIE C.;KOLSKY, KATHRYN L.;MAUSNER, LEONARD F.;SRIVASTAVA, SURESH C. |
发明人 |
MEASE, RONNIE C.;KOLSKY, KATHRYN L.;MAUSNER, LEONARD F.;SRIVASTAVA, SURESH C. |
分类号 |
A61K51/10;C07C233/41;G01N33/534;(IPC1-7):A61K51/08 |
主分类号 |
A61K51/10 |
代理机构 |
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代理人 |
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地址 |
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