发明名称 |
Medicinal products and pure preparations of melarsomine dihydrochloride, process for obtaining them and intermediate products obtained |
摘要 |
The medicinal product comprises as active principle a melarsomine hydrochloride preparation having a purity of between 98.5 and 100%. The process for obtaining this preparation is stated essentially as follows: step 1, trichlorotriazine (TCT) is converted to diaminochlorotriazine (DCT) in an ammoniacal medium; step 2, the DCT is converted to melarsen acid hydrochloride (MAH) in the presence of arsanilic acid; step 3, the MAH is reduced to melarsen oxide dihydrate; and step 4, the melarsen oxide dihydrate is converted to melarsomine dihydrochloride in the presence of cysteamine hydrochloride. In each step, a purified preparation of the corresponding intermediate product, or final product in step 4, is obtained.
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申请公布号 |
US5635499(A) |
申请公布日期 |
1997.06.03 |
申请号 |
US19950459797 |
申请日期 |
1995.06.02 |
申请人 |
MERIEUX, RHONE |
发明人 |
FLOC'H, ROBERT;ETCHEGARAY, JEAN-PIERRE;WOLF, GERARD;LUBERT, PATRICK;MAZARS, REGINE J. A. M. |
分类号 |
A61K9/14;A61K9/19;A61K31/53;A61K31/555;A61P33/02;C07F9/74;C07F9/78;C07F9/80;(IPC1-7):C07D251/70 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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