发明名称 |
Multi-unit ribozyme inhibition of oncogene gene expression |
摘要 |
A novel multi-unit ribozyme is provided which is capable of selectively cleaving the mRNA transcript of a hybrid oncogene resulting from a chromosomal translocation. Specialized delivery vehicles such as liposomes, and growth factor conjugates for cellular uptake by receptor-mediated endocytosis, are also described. The multi-unit ribozyme is used for the treatment of neoplasms characterized by expression of the oncogene. In one embodiment, a multi-unit ribozyme is provided which cleaves the mRNA transcript of Philadelphia chromosome-positive cells, thereby blocking production of the tumorigenic p210bcr-abl fusion protein.
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申请公布号 |
US5635385(A) |
申请公布日期 |
1997.06.03 |
申请号 |
US19930122795 |
申请日期 |
1993.09.15 |
申请人 |
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
LEOPOLD, LANCE H.;SHORE, SCOTT K.;REDDY, MOOLE V. R.;REDDY, E. PREMKUMAR |
分类号 |
A61K38/00;A61K47/48;A61K48/00;C12N15/113;(IPC1-7):C12N5/08;C12N5/16;C12N15/85;C07H21/02 |
主分类号 |
A61K38/00 |
代理机构 |
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