PROCESS FOR THE PRODUCTION OF CLAVULANIC ACID AND/OR SALTS THEREOF

摘要

A batch fermentation is carried out continuously or semicontinuously using strains of Streptomyces clavuligerus ATCC 27064 or mutants thereof. The fermentation process is carried out with a strict control of the soluble phosphate in the medium, both at the beginning and throughout the process. As a carbon source, lipids, preferably triglycerides can be used. Substantial increases in the production of the antibiotic are obtained.