发明名称 AZAHEXANE DERIVATIVES AS SUBSTRATE ISOSTERS OF RETROVIRAL ASPARATE PROTEASES
摘要 The invention relates to compounds of formula (I): wherein R1 and R10 are each independently of the other lower alkoxycarbonyl; either R2, R3 and R4 are each independently of the other C1-C4alkyl and R7, R8 and R9 are each selected from hydrogen and C1-C4alkyl, with not more than 2 of the radicals being hydrogen; or R7, R8 and R9 are each independently of the other C1-C4alkyl and R2, R3 and R4 are each selected from hydrogen and C1-C4alkyl, with 1 or 2 of the radicals being hydrogen; R5 is phenyl or cyclohexyl; and R6 is phenyl or cyanophenyl; or salts thereof; those compounds are inhibitors of retroviral aspartate proteases and are effective, for example, against HIV.
申请公布号 CA2237016(A1) 申请公布日期 1997.05.29
申请号 CA19962237016 申请日期 1996.11.13
申请人 NOVARTIS AG;NOVARTIS AG 发明人 F SSLER, ALEXANDER;BOLD, GUIDO;LANG, MARC;CAPRARO, HANS-GEORG
分类号 A61K31/00;A61K31/27;A61K31/275;A61P31/00;A61P31/18;A61P43/00;C07C271/22;(IPC1-7):C07C271/22 主分类号 A61K31/00
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