发明名称 |
SULFONAMIDE INHIBITORS OF MATRIX METALLOPROTEINASES |
摘要 |
Sulfonamide compounds are described which are inhibitors of matrix metalloproteinases, particularly stromelysin-1 and gelatinase A (72 kD gelatinase). Also described are methods for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes using the compounds.
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申请公布号 |
WO9719068(A1) |
申请公布日期 |
1997.05.29 |
申请号 |
WO1996US16761 |
申请日期 |
1996.10.18 |
申请人 |
WARNER-LAMBERT COMPANY;ORTWINE, DANIEL, FRED;PURCHASE, CLAUDE, FORSEY, JR.;WHITE, ANDREW, DAVID |
发明人 |
ORTWINE, DANIEL, FRED;PURCHASE, CLAUDE, FORSEY, JR.;WHITE, ANDREW, DAVID |
分类号 |
C07D211/10;C07D211/14;C07D295/096;C07D401/12;(IPC1-7):C07D295/08;A61K31/495;A61K31/445 |
主分类号 |
C07D211/10 |
代理机构 |
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