发明名称 |
Anti-T-cell receptor determinants as autoimmune disease treatment |
摘要 |
<p>Polymorphic regions of the variable region gene of T-cell receptors can be identified as being associated with particular autoimmune diseases. By detecting the presence of the particular sequence in the host genome, particularly rearranged, or the T-cell receptor expression product, the propensity for the autoimmune disease may be diagnosed. In addition, antibodies or peptides related to the specific sequence may be prepared for use in prophylaxis and therapy.</p> |
申请公布号 |
EP0340109(B1) |
申请公布日期 |
1997.05.28 |
申请号 |
EP19890401190 |
申请日期 |
1989.04.26 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
STEINMAN, LAWRENCE;ZAMVIL, SCOTT S.;MITCHELL, DENNIS J. |
分类号 |
G01N33/564;A61K31/00;A61K38/00;A61K39/395;A61P37/00;A61P37/02;C07K14/005;C07K14/195;C07K14/705;C07K16/00;C07K16/28;C12N15/02;C12N15/09;C12P21/02;C12P21/08;C12Q1/68;C12R1/91;G01N33/577;(IPC1-7):C12Q1/68 |
主分类号 |
G01N33/564 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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