OLIGONUCLEOTIDE MODULATION OF PROTEIN KINASE C

摘要

New nucleic acid sequences are provided which encode 3' untranslated regions of human protein kinase C alpha . Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C alpha . Oligonucleotides are provided which are specifically hybridizable with nucleic acid encoding PKC alpha . Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to PKC are disclosed. Polynucleotide probes for PKC alpha are also disclosed.