Secretory leukocyte protease inhibitor as an inhibitor of tryptase

摘要

This invention concerns methods of treating mast-cell mediated conditions in mammals, the methods comprising administering to the mammals pharmacologically active fragments or muteins of SLPI; methods of treating asthma or allergic rhinitis in mammals, the methods comprising administering to the mammals SLPI or pharmacologically active fragments or muteins thereof; methods for inhibiting tryptase; methods for identifying inhibitors of tryptase; and certain fragments and muteins of SLPI.