发明名称 |
ALL-1 polynucleotides for leukemia detection and treatment |
摘要 |
Methods are provided for the diagnosis and treatment of human leukemias involving breakpoints on chromosome 11 in the ALL-1 locus. The ALL-1 breakpoint region, an approximately 8 kb region on chromosome 11 is also disclosed. The ALL-1 region is involved in translocations in acute lymphocytic, mylemonocytic, monocytic, and myelogenous leukemias. Probes which identify chromosome aberrations involving the ALL-1 breakpoint region on chromosome 11 are also provided. The cDNA sequence of the ALL-1 gene on chromosome 11 is provided. A partial sequence of the AF-4 gene is also provided in the context of the sequences of the two reciprocal end products of a translocation. Amino acid sequences corresponding to the cDNA sequences of the entire ALL-1 gene and the partial sequence of the AF-4 gene are also provided. Probes are provided for detecting chromosomal abnormalities involving the ALL-1 gene on chromosome 11. Monoclonal antibodies for diagnosis and treatment and antisense oligonucleotides for the treatment of acute leukemias are also described.
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申请公布号 |
US5633136(A) |
申请公布日期 |
1997.05.27 |
申请号 |
US19940327392 |
申请日期 |
1994.10.19 |
申请人 |
THOMAS JEFFERSON UNIVERSITY |
发明人 |
CROCE, CARLO;CANAANI, ELI |
分类号 |
A61K38/00;C07K14/82;C07K16/32;C12Q1/68;(IPC1-7):C12Q1/68;C07H21/02;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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