| 摘要 |
To provide a process for the total synthesis of a cyclic peptide, which is useful as antifungal drug, and novel compounds prepared by the synthesis method. A process for synthesizing a cyclic peptide represented by the following formula (I): <IMAGE> (I) wherein X1, X2, X4 and X7 are independently N-methyl- alpha -amino acid or alpha -hydroxy acid, provided that at least one of X1, X2, X4 and X7 is a alpha -hydroxy acid; X3, X6 and X8 are independently alpha -amino acid; X5 is a cyclic amino acid; X9 is a N-methyl- alpha -amino acid or alpha -hydroxy acid substituted by a hydroxy group; and the dotted lines represent intramolecular hydrogen bonds; which process comprises cyclizing a corresponding linear peptide between X5 and X6 via a peptide bond, and a novel compound represented by the formula (I).
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