发明名称 |
19-nor-vitamin D compounds |
摘要 |
This invention provides a novel class of vitamin D-related compounds, namely the 1 alpha -hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells, and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided.
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申请公布号 |
US5633241(A) |
申请公布日期 |
1997.05.27 |
申请号 |
US19950442488 |
申请日期 |
1995.05.16 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
DELUCA, HECTOR F.;SCHNOES, HEINRICH K.;PERLMAN, KATO L.;SICINSKI, RAFAL R.;PRAHL, JEAN M. |
分类号 |
A61K31/59;A61K;A61P5/12;A61P17/00;A61P35/00;A61P35/02;C07C;C07C401/00;C12N;G01N33/48;G01N33/574;(IPC1-7):A61K31/59;A61K31/695 |
主分类号 |
A61K31/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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