PROCESS FOR THE PREPARATION OF 9-[(2-HYDROXYETHOXY)METHYL]GUANINE

摘要

There is described a process for the preparation of acyclovir by hydrolysis of N<2>-acetyl-9-(2-acetoxyethoxymethyl)guanine with monoethanolamine and isolation of acyclovir by neutralization with an acid and filtration. There is furthermore described a method for the purification of acyclovir by transformation of it into one of its alkali metal salts and neutralization of the alkali metal salt thus obtained.