| 发明名称 |
NIMA INTERACTING PROTEINS |
| 摘要 |
A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting proteins and identifying compositions which affect Pin activity or expression are also provided.
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| 申请公布号 |
CA2235225(A1) |
申请公布日期 |
1997.05.22 |
| 申请号 |
CA19962235225 |
申请日期 |
1996.10.28 |
| 申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES;THE SALK INSTITUTE FOR BIOLOGICAL STUDIES |
发明人 |
HUNTER, TONY;LU, KUN PING |
| 分类号 |
A61K38/00;C12N9/90;(IPC1-7):C12N15/61;C12Q1/02;A61K39/395;C07K16/40;C12Q1/48;C12Q1/533;G01N33/573;C12Q1/68;A61K31/70 |
主分类号 |
A61K38/00 |
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